TheSugarScience Podcast- curating the scientific conversation in type 1 diabetes

Episode 74: Toby Coates, PhD, Professor of Medicine at the University of Adelaide

In this episode, Dr. Toby Coates joins us to give us some insights into his work with the Biodegradable Temporizing Matrix (BTM). 

Episode 73: Matthieu Raoux, PhD, HDR, Associate Professor, University of Bordeaux, France

In this episode, Matthieu Raoux joins us to talk about his fascinating research at the University of Bordeaux, France. Dr. Raoux provides insights to his recent publication: Dynamic Uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets.

" Our data provide a new uni- and multicellular model of islet β-cell activation: during the 1st phase, small but highly active β-cell clusters are dominant, whereas during the 2nd phase electrical coupling generates large functional clusters via multicellular slow potentials to favor an economic sustained activity."

 

Checkout his latest publication!

Episode 72: Noel G. Morgan, PhD, Professor of Endocrine Pharmacology and Director of the Institute of Biomedical & Clinical Science at the University of Exeter

In this episode, Professor Noel G. Morgan joins us to discuss his work in cellular pharmacology and studying the pathophysiology of pancreatic beta-cells in diabetes. He also talks about his work with B cells and a recent publication, "Footprints of Immune Cells in the Pancreas in Type 1 Diabetes; to “B” or Not to “B”: Is That Still the Question?". 

Link to his paper: https://www.frontiersin.org/articles/10.3389/fendo.2021.617437/full

Episode 71: Alok Joglekar, PhD, Assistant Professor at University of Pittsburgh School of Medicine

In this episode, we speak with Alok Joglekar about his fantastic research at the University of Pittsburg. Dr. Joglekar provides us with some insights to his publication: T cell antigen discovery. T cells play a critical role in the elimination of pathogens and the surveillance of pathological cells.

 

Read the full text here

Episode 70: Matthias von Herrath, MD, Professor at the La Jolla Institute for Immunology and Vice President and Senior Medical Officer at Novo Nordisk

In this episode, Dr. Matthias von Herrath joins us to discuss his work at the La Jolla Institute for Immunology and at pharmaceutical company Novo Nordisk. He discusses one of his recently published papers, "Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial". 

Full paper link: https://www.thelancet.com/journals/landia/article/PIIS2213-8587(21)00019-X/fulltext 

Episode 69: Hans Sollinger, MD, PhD, Founder & Interim CSO of Endsulin

In this episode, we speak to Dr. Hans Sollinger, MD, PhD, Founder & Interim CSO of Endsulin. Dr. Sollinger has been a leader in diabetes care for decades and has revolutionized the field twice. 

 

Endsulin is overcoming the limitations of today's taxing diabetes treatments with a patented gene construct and simple process that re-engineers part of the liver, allowing it to produce and regulate insulin on its own.

Learn more about Endsulin here!

Episode 68: Burcak Yesildag, PhD, Head of Islet Solutions at InSphero

In this episode, Burcak Yesildag joins us to discuss her work in the Islet Solutions Group at InSphero, generating advanced and high-throughput compatible assays and disease models for diabetes drug discovery. She also gives us some insight into a recent publication, "Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes". 

Full paper: Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes

To learn more about InSphero: https://insphero.com/ 

Episode 67: Arun Sridhar, PhD, Co- Founder Skraps & Philippe Blancou, PhD, Professor at CNRS- Centre National de la Recherche Scientifique

In this episode, Arun Sridhar and Philippe Blancou join us to discuss their innovative work in the type 1 diabetes space. These researchers provide us details about one of their recent publications: Pancreatic nerve electrostimulation inhibits recent-onset autoimmune diabetes. 

Arun Sridhar is the host of Skraps, a top 10% rated scientific podcast. Tune in to listen to stories of scientific brilliance!

 

 

 

Episode 66: Ying Liu, PhD, and graduate students Paola Leon Plata and Maryam Zaroudi from University of Illinois at Chicago

In this episode, Dr. Ying Liu along with PhD students Paola Leon Plata and Maryam Zaroudi join us to talk about their recent publication, "Heterogeneous Toroidal Spiral Particles for Islet Encapsulation". Liu Laboratory at the University of Illinois Chicago Department of Chemical Engineering focuses on nano- and micro- materials to address current challenges in drug delivery and tissue engineering. 

Click here for the full paper, and here to learn more about Liu Laboratory. 

Episode 65: Laia Gómez Muñoz, PhD student in Immunology, Germans Trias i Pujol Research Institute (IGTP)

In this episode, Laia Gómez Muñoz joins us to discuss her recent publication, NK Cell Subsets Changes in Partial Remission and Early Stages of Pediatric Type 1 Diabetes.

Laia is a PhD student at the Immunology of Diabetes Group under the supervision of Dra. Marta Vives. Her research focuses on the identification of new biomarkers of partial remission in pediatric patients with autoimmune diabetes for their application in immunological monitoring and clinical trials.